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Proteintech
FRS3 Polyclonal Antibody
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产品信息
12249-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
FRS3 Fusion Protein Ag2896 (1-303 aa encoded by BC010611)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MGSCCSCLN RDSVPDNHPT KFKVTNVDDE GVELGSGVME LTQSELVLHL HRREAVRWPY LCLRRYGYDS NLFSFESGRR CQTGQGIFAF KCSRAEEIFN LLQDLMQCNS INVMEEPVII TRNSHPAELD LPRAPQPPNA LGYTVSSFSN GCPGEGPRFS APRRLSTSSL RHPSLGEEST HALIAPDEQS HTYVNTPASE DDHRRGRHCL QPLPEGQAPF LPQARGPDQR DPQVFLQPGQ VKFVLGPTPA RRHMVKCQGL CPSLHDPPHH NNNNEAPSEC PAQPKCTYEN VTGGLWRGAG WRLS (1-303 aa encoded by BC010611)
靶标信息
FRS3 (fibroblast growth factor receptor substrate 3), also known as FRS2B (FRS2-beta), is a 492 amino acid lipid-anchor adapter protein that contains one IRS-type PTB domain. Colocalizing to neural tissues with Tuj1, FRS3 functions as a feedback inhibitor of EGFR family members by preventing heterodimer formation between EGFR and ErbB2, thereby acting as a potential tumor suppressor. FRS3 is phosphorylated upon stimulation by FGF-2 or NGF and, acting as an adapter protein, links c-Fgr and NGF receptors to downstream signaling pathways. Interfering with the phosphorylation and nuclear translocation of ERK-2, FRS3 down-regulates ERK-2 expression. FRS3 likely interacts directly with GRB2, SH-PTP2, Flg, and Trk A, and may be involved in MAP kinase activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FGFR substrate 3; FGFR-signaling adaptor SNT2; Fibroblast growth factor receptor substrate 3; FRS2-beta; SNT-2; Suc1-associated neurotrophic factor target 2; suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor); testicular tissue protein Li 71
基因别名: 4930417B13Rik; AI449674; FRS2-beta; FRS2B; FRS2beta; FRS3; SNT-2; SNT2
UniProt ID: (Human) O43559, (Rat) Q52RG8, (Mouse) Q91WJ0
Entrez Gene ID: (Human) 10817, (Rat) 316213, (Mouse) 107971
