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Invitrogen
FSTL3 Polyclonal Antibody
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FSTL3 Antibody (PA5-79285) in WB
Western blot analysis of FSTL3 in, Lane 1: human U2OS whole cell lysates, Lane 2: human Hela whole cell lysates, Lane 3: human A549 whole cell lysates, Lane 4: human PC-3 whole cell lysates, Lane 5: human HepG2 whole cell lysates, Lane 6: human K562 whole cell lysates. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50 µg of sample under reducing conditions. After Electrophoresis, proteins were transferred to a Nitrocellulose membr... View More
产品信息
PA5-79285
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence in the middle region of human FSTL3 (145-159aa ECELRAARCRGHPDL).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human U2OS whole cell, human Hela whole cell, human A549 whole cell, human PC-3 whole cell, human HepG2 whole cell, human K562 whole cell, rat liver tissue, rat testis tissue, rat NRK whole cell, mouse liver tissue, mouse testis tissue, mouse lung tissue.
靶标信息
Follistatin-like 3 (FSTL3) is a gene located on chromosome 19p13.3 and encodes a secreted glycoprotein that belongs to the follistatin-related protein family. FSTL3 functions as an antagonist to members of the transforming growth factor-beta (TGF-β) superfamily, particularly inhibiting activin and myostatin signaling. This inhibitory action is crucial for regulating muscle growth, fertility, and inflammation. FSTL3 is expressed in various tissues, including the placenta, gonads, and skeletal muscle, where it modulates physiological processes by binding to and neutralizing the activities of its target ligands. Dysregulation of FSTL3 has been implicated in conditions such as muscle wasting, metabolic syndrome, and reproductive disorders, reflecting its role in maintaining tissue homeostasis and function. Research into FSTL3 focuses on its potential therapeutic applications in diseases involving TGF-β pathway dysregulation, offering insights into strategies for modulating growth factor activities in clinical settings.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FLRGFSRP; follistatin-like 3 (secreted glycoprotein); Follistatin-like protein 3; Follistatin-related gene protein; Follistatin-related protein 3
基因别名: E030038F23Rik; FLRG; FSRP; FSTL3; UNQ674/PRO1308
UniProt ID: (Human) O95633, (Mouse) Q9EQC7, (Rat) Q99PW7
Entrez Gene ID: (Human) 10272, (Mouse) 83554, (Rat) 114031
ossification
kidney development
hematopoietic progenitor cell differentiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
male gonad development
positive regulation of cell-cell adhesion
lung development
adrenal gland development
negative regulation of BMP signaling pathway
negative regulation of activin receptor signaling pathway
negative regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
cellular response to metal ion
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of transcription, DNA-templated
