Invitrogen

FZD3 Monoclonal Antibody (169310)

查看其他13个FZD3抗体

问题与答案

问题与答案

产品信息

MA5-24379

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-10 µg/mL

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rat / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

169310

抗原

Mouse myeloma cell line NS0-derived recombinant mouse Frizzled-3 Met1-Val157

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.5 mg/mL

纯化类型

Protein A/G

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2577109

产品详细信息

In direct ELISAs, no cross-reactivity with recombinant mouse Frizzled-1, -4, -7, or -8 is observed. By flow cytometry and immunohistochemistry, this antibody also detects mouse Frizzled-3 on differentiated embryoid bodies derived from the mouse embryonic cell line, D3. This antibody also detects Frizzled-3 on human HEK293 cells by immunocytochemistry and flow cytometry.

Reconstitute at 0.5 mg/mL in sterile PBS.

靶标信息

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: frizzled 3, seven transmembrane spanning receptor; frizzled family receptor 3; frizzled homolog 3; Frizzled-3; Fz-3; hFz3; mFz3

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基因别名: AU020229; D930050A07Rik; Fz-3; Fz3; FZD3

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UniProt ID: (Human) Q9NPG1, (Mouse) Q61086

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Entrez Gene ID: (Human) 7976, (Mouse) 14365

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G-protein coupled receptor activity protein binding Wnt-protein binding PDZ domain binding Wnt-activated receptor activity signal transducer activity transmembrane signaling receptor activity transmembrane signal receptor

establishment of planar polarity neuron migration neural tube closure hair follicle development positive regulation of neuroblast proliferation G-protein coupled receptor signaling pathway Wnt signaling pathway, calcium modulating pathway neuron differentiation cell proliferation in midbrain non-canonical Wnt signaling pathway post-anal tail morphogenesis dopaminergic neuron axon guidance serotonergic neuron axon guidance inner ear morphogenesis negative regulation of mitotic cell cycle, embryonic canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway sympathetic ganglion development commissural neuron axon guidance negative regulation of execution phase of apoptosis midbrain morphogenesis signal transduction cell surface receptor signaling pathway multicellular organism development nervous system development Wnt signaling pathway midbrain development