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In direct ELISAs, no cross-reactivity with recombinant mouse Frizzled-1, -4, -7, or -8 is observed. By flow cytometry and immunohistochemistry, this antibody also detects mouse Frizzled-3 on differentiated embryoid bodies derived from the mouse embryonic cell line, D3. This antibody also detects Frizzled-3 on human HEK293 cells by immunocytochemistry and flow cytometry.
Reconstitute at 0.5 mg/mL in sterile PBS.
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: frizzled 3, seven transmembrane spanning receptor; frizzled family receptor 3; frizzled homolog 3; Frizzled-3; Fz-3; hFz3; mFz3
基因别名: AU020229; D930050A07Rik; Fz-3; Fz3; FZD3
UniProt ID: (Human) Q9NPG1, (Mouse) Q61086
Entrez Gene ID: (Human) 7976, (Mouse) 14365