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Invitrogen
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PA1-74106 detects Factor V from human samples.
The neutralizing activity of PA1-74106 is 27.5 Bethesda Units/ml IgG aginst normal plasma.
PA1-74106 has been successfully used in ELISA, immunoelectrophoresis, and inhibition assay applications.
The PA1-74106 immunogen is Factor V from human plasma.
Coagulation factor V (or Proaccelerin) is an essential factor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The active factor V is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in the Factor V gene can result various diseases including Factor V deficiency, thrombophilia due to activated protein C resistance, Budd-Chiari syndrome, Ischemic stroke, and recurrent pregnancy loss.
仅用于科研。不用于诊断过程。未经明确授权不得转售。