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PA1-74115 detects Factor XI from human samples.
PA1-74115 has been successfully used in ELISA applications.
The PA1-74115 immunogen is Factor XI from human plasma.
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Coagulation factor XI; Coagulation factor XIa heavy chain; Coagulation factor XIa light chain; FXI; Plasma thromboplastin antecedent; PTA
基因别名: F11