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Immunogen sequence: SKALSGFSLQ SCRHSIPVFC HSSFYHDTDF LGEELDIVAA KSHEACQKLC TNAVRCQFFT YTPAQASCNE GKGKCYLKLS SNGSPTKI
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Coagulation factor XI; FXI; Plasma thromboplastin antecedent; PTA
基因别名: F11; FXI
UniProt ID: (Human) P03951
Entrez Gene ID: (Human) 2160