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Invitrogen
FceR1 alpha Recombinant Armenian Hamster Monoclonal Antibody (Mar-1)
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产品信息
MA5-51873
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Armenian hamster
/ IgG, lambda
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
Mar-1
抗原
Mouse Fc epsilon receptor alpha subunit.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody specifically targets the non-signalling alpha chain of the FceR1 complex.
靶标信息
Fc epsilon RI alpha, also known as FceR1 alpha, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. Fc epsilon RI alpha forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The Fc epsilon RI complex plays a crucial role in triggering IgE-mediated allergic reactions. When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms. This process couples allergens and mast cells to initiate inflammatory responses characteristic of allergic disorders like hay fever and asthma. The release of histamine and proteases also leads to the synthesis of prostaglandins and leukotrienes, which are potent effectors of the hypersensitivity response.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: fc epsilon r1; Fc-epsilon RI-alpha; FcERI; High affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; RP11-550P17.3
基因别名: Fce1a; fcepsilonri; Fcer1a; FcERI; Fcr-5
UniProt ID: (Mouse) P20489
Entrez Gene ID: (Mouse) 14125
activation of MAPK activity
positive regulation of type I hypersensitivity
serotonin secretion
signal transduction
cell surface receptor signaling pathway
activation of JUN kinase activity
leukotriene biosynthetic process
Fc-epsilon receptor signaling pathway
positive regulation of mast cell degranulation
positive regulation of interleukin-3 biosynthetic process
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of calcium-mediated signaling
