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Invitrogen
Fenfluramine Recombinant Mouse Monoclonal Antibody (1B3)
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Fenfluramine Antibody (MA566508) in SDS-PAGE
SDS-PAGE characterization of Fenfluramine under reducing conditions. Lane M: Protein marker (kDa); Lane FFRM: Purified Fenfluramine Recombinant Monoclonal (Product # MA566508). Fenfluramine showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-648.
产品信息
MA566508
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1B3
抗原
Conjugate of FFRM hapten and KLH.
偶联物
形式
Liquid
浓度
9.6 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Fenfluramine is a synthetic amphetamine derivative primarily known for its appetite suppressant properties, but it has been repurposed for use in treating epilepsy, particularly Dravet syndrome. The compound is characterized by its trifluoromethyl group, which has been substituted by the pentafluorosulfanyl group in analogs to enhance selectivity and efficacy as inhibitors of 5-hydroxytryptamine receptors. Fenfluramine's mechanism involves modulation of serotonin pathways, contributing to its therapeutic effects and potential adverse cardiovascular impacts. The NAV1.1 voltage-gated sodium channel gene is implicated in its anticonvulsant activity, highlighting the drug's multifaceted role in neuropharmacology. Fenfluramine's biosimilar development focuses on optimizing its molecular structure for improved safety and efficacy in clinical applications.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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