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PA1-28861 detects Fibrinogen from human samples.
PA1-28861 has been successfully used in ELISA, Western blot, Dot blot, immunomicroscopy, and immunohistochemistry (frozen tissue) applications.
The PA1-28861 immunogen is fibrinogen [Human Plasma]
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
Fibrinogen, the precursor of fibrin, is the coagulable protein in the blood plasma of vertebrates. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. Fibrinogen consists as a dimer of 3 pairs of non-identical chains FGA, FGB, and FGG that are cross-linked by disulfide bonds in their N-terminal segments. The molecule has 2 terminal D domains and one central E domain, all three domains are separated when fibrinogen is degradated by plasmin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, afibrinogenemia, and renal amyloidosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。