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Invitrogen
Fra1 Recombinant Rabbit Monoclonal Antibody (PSH06-95)
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Fra1 Antibody (MA562090) in WB
Western blot was performed using Fra1 Recombinant Rabbit Monoclonal Antibody (PSH06-95) (Product # MA562090) and a 38 kDa band corresponding to FRA1 was observed in BT-549 and U-87 MG which are high expressors of FRA1, but was not detected in MCF7 and SH-SY5Y which are low expressors of FRA1. Nuclear enriched extracts (30 µg lysate) of BT-549 (Lane 1), MCF7 (Lane 2), SH-SY5Y (Lane 3), U-87MG (Lane 4) and HT-29 (Lane 5) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX), 12 well. Resolved proteins were then ... View More
产品信息
MA562090
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH06-95
抗原
Recombinant protein within human FRA1 aa 1-271.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive Control: HeLa starved for 24 hours then add 100 ng/mL TPA for 4 hours cell lysate.
Tissue Specificity: Tissue enhanced (adipose tissue, urinary bladder).
Subcellular Location: Nucleus.
Sequence Similarities: 90%Mouse/Rat.
Predicted band size: 29 kDa.
靶标信息
The v-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. Members of the c-Fos gene family, including c-Fos, Fos B, Fra-1 and Fra-2, encode nuclear phosphoproteins that are rapidly and transiently induced by a variety of agents and function as transcriptional regulators for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers that bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FOS like 1, AP-1 trancription factor subunit; FOS like antigen 1; FOS-like antigen 1; FOS-like antigen-1; Fos-related antigen 1; FRA-1; HGNC:13718
基因别名: FOSL1; FRA; fra-1; FRA1
UniProt ID: (Human) P15407
Entrez Gene ID: (Human) 8061
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
basic leucine zipper transcription factor
in utero embryonic development
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
chemotaxis
cellular defense response
vitellogenesis
female pregnancy
learning
positive regulation of cell proliferation
negative regulation of cell proliferation
response to mechanical stimulus
response to virus
response to gravity
cellular response to extracellular stimulus
response to progesterone
response to cytokine
response to drug
response to hydrogen peroxide
positive regulation of apoptotic process
positive regulation of cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
response to corticosterone
response to cAMP
placenta blood vessel development
pri-miRNA transcription from RNA polymerase II promoter
positive regulation of DNA-templated transcription, initiation
