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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Furin Antibodies

          Invitrogen

          Furin Recombinant Rabbit Monoclonal Antibody (JB35-53)

          查看其他13个Furin抗体

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          说明书
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          说明书
          实验方案
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          Cite Furin Recombinant Rabbit Monoclonal Antibody (JB35-53)

          • 抗体检测数据 (5)
          Furin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Furin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          图: 1 / 5

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          Furin Antibody (MA5-34677) in IHC (P)

          Immunohistochemistry analysis of Furin in paraffin-embedded human placenta tissue. Samples were incubated with Furin monoclonal antibody (Product # MA5-34677), and followed by hematoxylin. {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
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          查看产品

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          Furin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Furin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Furin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Furin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Furin Antibody in Western Blot (WB)

          产品信息

          MA5-34677

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:500-1:1,000
          -

          免疫组化(石蜡) (IHC (P))

          1:50
          -
          产品规格

          种属反应

          Human

          宿主/亚型

          Rabbit / IgG

          Expression System

          HEK293 cells

          分类

          Recombinant Monoclonal

          类型

          Antibody

          克隆号

          JB35-53

          抗原

          Recombinant protein within Human Furin aa 261-310
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1 mg/mL

          纯化类型

          Protein A

          保存液

          TBS, pH 7.4, with 40% glycerol, 0.05% BSA

          内含物

          0.05% sodium azide

          保存条件

          -20°C, Avoid Freeze/Thaw Cycles, store in dark

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2848585

          产品详细信息

          Positive Control: HepG2, Hela, MCF-7, human liver tissue, human colon tissue, human placenta tissue, mouse brain tissue.

          靶标信息

          Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase (PC) family. Members of this family of cellular enzymes cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. Furin and other PC family members share structural similarities which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. Furin is the only known PC to possess a transmembrane domain. Cleavage of target proteins occurs at the carboxyl-terminus of the furin consensus sequence, RX(K/R)R. It has been shown that the acidic peptide sequence, C771PSDSEEDEG780, localizes furin to the trans-Golgi-network. Phosphorylation of serine residues within this region modulates intracellular routing of furin protein. An additional signaling domain includes the tetrapeptide sequence, Y759KGL762, which directs internalization from the cell surface.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: dibasic processing enzyme; Dibasic-processing enzyme; FES upstream region; Furin; furin (paired basic amino acid cleaving enzyme); furin, membrane associated receptor protein; PACE; Paired basic amino acid residue-cleaving enzyme; proprotein convertase subtilisin/kexin type 3

          查看更多 收起

          基因别名: FUR; FURIN; PACE; PCSK3; SPC1

          查看更多 收起

          UniProt ID: (Human) P09958

          查看更多 收起

          Entrez Gene ID: (Human) 5045

          查看更多 收起

          功能
          protease binding endopeptidase activity serine-type endopeptidase activity serine-type endopeptidase inhibitor activity protein binding peptidase activity peptide binding metal ion binding nerve growth factor binding serine protease
          参与通路
          signal peptide processing transforming growth factor beta receptor signaling pathway aging cell proliferation negative regulation of endopeptidase activity protein processing peptide hormone processing viral life cycle viral protein processing extracellular matrix disassembly extracellular matrix organization positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway collagen catabolic process nerve growth factor processing negative regulation of low-density lipoprotein particle receptor catabolic process nerve growth factor production negative regulation of nerve growth factor production negative regulation of transforming growth factor beta1 production secretion by cell regulation of protein catabolic process peptide biosynthetic process cellular protein metabolic process regulation of low-density lipoprotein particle receptor biosynthetic process positive regulation of membrane protein ectodomain proteolysis regulation of endopeptidase activity
          It has to be done as per old AB suggested Products section.
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          性能保障

          只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符,您即可享受免费退换货服务。*

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