Invitrogen

Furin Recombinant Rabbit Monoclonal Antibody (JB35-53)

Furin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Furin Antibody (MA5-34677) in IHC (P)

Immunohistochemistry analysis of Furin in paraffin-embedded human placenta tissue. Samples were incubated with Furin monoclonal antibody (Product # MA5-34677), and followed by hematoxylin.

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产品信息

MA5-34677

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化（石蜡） (IHC (P))

1:50

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

JB35-53

抗原

Recombinant protein within Human Furin aa 261-310

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles, store in dark

运输条件

Ambient (domestic); Wet ice (international)

AB_2848585

产品详细信息

Positive Control: HepG2, Hela, MCF-7, human liver tissue, human colon tissue, human placenta tissue, mouse brain tissue.

靶标信息

Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase (PC) family. Members of this family of cellular enzymes cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. Furin and other PC family members share structural similarities which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. Furin is the only known PC to possess a transmembrane domain. Cleavage of target proteins occurs at the carboxyl-terminus of the furin consensus sequence, RX(K/R)R. It has been shown that the acidic peptide sequence, C771PSDSEEDEG780, localizes furin to the trans-Golgi-network. Phosphorylation of serine residues within this region modulates intracellular routing of furin protein. An additional signaling domain includes the tetrapeptide sequence, Y759KGL762, which directs internalization from the cell surface.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: dibasic processing enzyme; Dibasic-processing enzyme; FES upstream region; Furin; furin (paired basic amino acid cleaving enzyme); furin, membrane associated receptor protein; PACE; Paired basic amino acid residue-cleaving enzyme; proprotein convertase subtilisin/kexin type 3

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基因别名: FUR; FURIN; PACE; PCSK3; SPC1

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UniProt ID: (Human) P09958

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Entrez Gene ID: (Human) 5045

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功能