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Invitrogen
Fyn Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-120612
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Fyn (NP_002028.1).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.88 mg/mL
Amount
88 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: Mouse testis, Mouse brain, Rat brain. The target is usually found in the following locations: Cell membrane, Cytoplasm, Nucleus.
Immunogen sequence: VKHYKIRKLD NGGYYITTRA QFETLQQLVQ HYSERAAGLC CRLVVPCHKG MPRLTDLSVK TKDVWEIPRE SLQLIKRLGN GQFGEVWMGT WNGNTKVAIK T
Target Information
FYN is a SRC-related kinase expressed in brain, skeletal muscle and adipose tissues. Fyn functions in a large number of pathways and has been shown to play a role in memory. FYN is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C syn protooncogene; EC 2.7.10.2; FYN oncogene related to SRC, FGR, YES; fyn {ECO:0000312|RGD:2641}; kinase Fyn; MGC45350; OTTHUMP00000017916; OTTHUMP00000017917; P59 p59-Fyn; p59-Fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; proto-oncogene tyrosine-protein kinase Fyn; Protooncogene Syn; RP1-66H14.1; SLK; Src Kinase p59; Src like kinase; Src-like kinase; Tyrosine-protein kinase Fyn
Gene Aliases: AI448320; AW552119; FYN
UniProt ID: (Rat) Q62844, (Mouse) P39688
Entrez Gene ID: (Rat) 25150, (Mouse) 14360
G-protein coupled receptor binding
glycoprotein binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
tubulin binding
protein complex binding
T cell receptor binding
CD4 receptor binding
CD8 receptor binding
phosphatidylinositol 3-kinase binding
ion channel binding
metal ion binding
ephrin receptor binding
peptide hormone receptor binding
growth factor receptor binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
neuron migration
protein phosphorylation
cell surface receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
central nervous system development
regulation of cell shape
negative regulation of gene expression
positive regulation of neuron projection development
positive regulation of phosphatidylinositol 3-kinase signaling
cell migration
peptidyl-tyrosine phosphorylation
cell differentiation
forebrain development
negative regulation of protein ubiquitination
ionotropic glutamate receptor signaling pathway
cellular response to platelet-derived growth factor stimulus
peptidyl-tyrosine autophosphorylation
T cell activation
regulation of cell proliferation
negative regulation of protein catabolic process
response to drug
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of neuron apoptotic process
innate immune response
response to ethanol
protein autophosphorylation
dendrite morphogenesis
activated T cell proliferation
T cell receptor signaling pathway
detection of mechanical stimulus involved in sensory perception of pain
cellular response to growth factor stimulus
cellular response to peptide hormone stimulus
cellular response to transforming growth factor beta stimulus
positive regulation of protein localization to nucleus
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
immune system process
multicellular organism development
phosphorylation
myelination
regulation of apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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