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Invitrogen
GABARAP Polyclonal Antibody
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GABARAP Antibody (PA1-18289) in WB
Western blot was performed using Anti-GABARAP Rabbit Polyclonal Antibody (Product # PA1-18289) and 14 kDa band corresponding to GABARAP were observed in HeLa cell line tested. Membrane enriched extracts (30 µg lysate) of HeLa (Lane 1) and HeLa treated with 50 µM Chloroquine for 20 hours (Lane 2) were electrophoresed using NuPAGE™ 12% Bis-Tris Protein Gel (Product # NP0342BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed w... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-18289
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the N-terminal residues of human GABARAP.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
靶标信息
Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: epididymis secretory sperm binding protein; FLJ25768; GABA(A) receptor-associated protein; GABARAP; GABARAP a; MGC120154; MGC120155; unnamed protein product
基因别名: ATG8A; GABARAP-a; MM46
UniProt ID: (Human) O95166, (Rat) P60517
Entrez Gene ID: (Human) 11337, (Rat) 58974
autophagosome assembly
microtubule cytoskeleton organization
mitophagy
cellular response to nitrogen starvation
extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of Rac protein signal transduction
reticulophagy
autophagosome maturation
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
positive regulation of protein K48-linked ubiquitination
negative regulation of TORC1 signaling
protein targeting
chemical synaptic transmission
positive regulation of lysosome organization
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