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This antibody is predicted to react with chicken, human, mouse, non-human primate and zebrafish based on 100% sequence homology. The antigenic sequence has no homology with any other GABA-A receptor or alpha and beta subunits.
In Western blot, this antibody detects a ~45 kDa to ~47 kDa protein representing GABA-A receptor gamma 2 in rat brain membranes.
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: GABA(A) receptor subunit gamma-2; GABRA2; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor, gamma 2; gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2; gamma-aminobutyric acid A receptor, gamma 2; Gamma-aminobutyric acid receptor subunit gamma-2
基因别名: GABAA-R; Gabrg-2; Gabrg2; gamma2
UniProt ID: (Mouse) Q91V50, (Rat) P18508
Entrez Gene ID: (Mouse) 14406, (Rat) 29709
分子生物学功能: ligand-gated ion channel