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NeoBiotechnologies
GAD1/GAD67 Monoclonal Antibody (GAD1, 2391)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
2571-MSM1-P1ABX
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
GAD1, 2391
抗原
Recombinant human GAD1 (GAD67) protein fragment (around aa 72-135)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is tested in direct ELISA.
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
靶标信息
GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predominant GAD-67 form and the minor GAD-25 form.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 67 kDa glutamic acid decarboxylase; FLJ45882; GAD; GAD 1; GAD 67; GAD67 short splice variant; glutamate decarboxylase 1 (brain 67kDa) isoform GAD1_1; glutamate decarboxylase 1 (brain 67kDa) isoform GAD1_2; glutamate decarboxylase 1 (brain 67kDa) isoform GAD1_3; glutamate decarboxylase 1 (brain, 67kDa); OTTHUMP00000041055; unnamed protein product
基因别名: CPSQ1; DEE89; GAD; GAD-67; SCP
UniProt ID: (Human) Q99259
Entrez Gene ID: (Human) 2571
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