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Proteintech
GADD45A Polyclonal Antibody
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产品信息
13747-1-AP
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GADD45A Fusion Protein Ag4687 (5-165 aa encoded by BC011757)
偶联物
形式
Liquid
浓度
0.17 mg/mL
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: EFSAGEQKT ERMDKVGDAL EEVLSKALSQ RTITVGVYEA AKLLNVDPDN VVLCLLAADE DDDRDVALQI HFTLIQAFCC ENDINILRVS NPGRLAELLL LETDAGPAAS EGAEQPPDLH CVLVTNPHSS QWKDPALSQL ICFCRESRYM DQWVPVINLP ER (5-165 aa encoded by BC011757)
靶标信息
GADD45 alpha, beta and gamma are an evolutionarily conserved, homologous family of nuclear proteins that function as stress sensors for cellular physiological and environmental damage. GADD45 proteins are required for the activation of the G2/M checkpoint induced by UV radiation or alkylating agents. GADD45-induced G2/M checkpoint is regulated through inactivation of Cdc2-cyclin B1 kinase. GADD45 forms a complex with p21 and Cdc2, and may serve as core for interaction with other cell cycle regulators.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
