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Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N- acetylgalactosaminyltransferases catalyze the transfer of an N- acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: GalNAc-T11; Polypeptide GalNAc transferase 11; Polypeptide N-acetylgalactosaminyltransferase 11; pp-GaNTase 11; Protein-UDP acetylgalactosaminyltransferase 11; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
基因别名: A430075I06Rik; AI648252; E430002F06Rik; GALNAC-T11; GALNACT11; GALNT11
UniProt ID: (Human) Q8NCW6, (Mouse) Q921L8, (Rat) Q6P6V1
Entrez Gene ID: (Human) 63917, (Mouse) 231050, (Rat) 311952