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Abnova
GAPVD1 Polyclonal Antibody, MaxPab™
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产品信息
H00026130-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GAPVD1 (AAH21119.1, 1 a.a. approximately 629 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MQEDESYLLQ VLRYLIEFEL KESDNPRRLL RRGTCAFSIL FKLFSEGLFS AKLFLTATLH EPIMQLLVED EDHLETDPNK LIERFSPSQQ EKLFGEKGSD RFRQKVQEMV ESNEAKLVAL VNKFIGYLKQ NTYCFPHSLR WIVSQMYKTL SCVDRLEVGE VRAMCTDLLL ACFICPAVVN PEQYGIISDA PINEVARFNL MQVGRLLQQL AMTGSEEGDP RTKSSLGKFD KSCVAAFLDV VIGGRAVETP PLSSVNLLEG LSRTVVYITY SQLITLVNFM KSVMSGDQLR EDRMALDNLL ANLPPAKPGK SSSLEMTPYN TPQLSPATTP ANKKNRLPIA TRSRSRTNML MDLHMDHEGS SQETIQEVQP EEVLVISLGT GPQLTPGMIS ENEVLNMQLS DGGQGDVPVD ENKLHGKPDK TLRFSLCSDN LEGISEGPSN RSNSVSSLDL EGESVSELGA GPSGSNGVEA LQLLEHEQAT TQDNLDDKLR KFEIRDMMGL TDDRDISETV SETWSTDVLG SDFDPNIDED RLQEIAGAAA ENMLGSLLCL PGSGSVLLDP CTGSTISETT SEAWSVEVLP SDSEAPDLKQ EERLQELESF LDWVAHLMIR MSGRSVPAPA HQASVLCPA
靶标信息
GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZP434C212; GAPex-5; GTPase-activating protein and VPS9 domain-containing protein 1; MGC138847; MGC138848; Rab5-activating protein 6
基因别名: GAPex-5; GAPEX5; GAPVD1; KIAA1521; RAP6
UniProt ID: (Human) Q14C86
Entrez Gene ID: (Human) 26130
