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Immunogen sequence: RKNEKSVVLC LLEVARRGAR LGLLAPRLVQ FEQEIERELR AAPPAPNAPA AGEDTTETAP APGTPARGPR MTPSDLRNLD ELVREILGRC TCPDQFPMIK VSEGKYRVGD SSLLIFVRVL RSHVMVRVGG GWDTLEHYLD KHDPCRCSST AHRPPQPRVC TFSPQRVSPT TSPRPASPVP GSERRGSRPE MTPVSLRSTK EGPETPPRPR DQLPPHPRSR RYSGDSDSSA SSAQSGPLGT RSDDTGTGPR RERPSRRLTT GTPASPRRPP A; Positive Samples: A673, 22Rv1; Cellular Location: Cytoplasm, cytoskeleton
The Gas2 protein is thought to play a role in apoptosis by acting as a cell death substrate for caspases. Gas2, a component of the microfilament system, is cleaved by a caspase (caspase-3 or caspase-7) at Asparagine 278 during apoptosis. The cleaved form of Gas2 dramatically induces the re-arrangement of the Actin cytoskeleton and causes potent changes in the shape of the affected cells. Gas2 is a cytoskeleton and peripheral membrane protein that co-localizes with Actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Gas2 is mainly membrane-associated, but when hyperphosphorylated it will accumulate at membrane ruffles, indicating Gas2 involvement in that process. Gar22 (Gas2-related protein on chromosome 22), also designated growth arrest-specific protein 2-like 1 (Gas2-like1), belongs to the Gas2 family and contains one CH (calponinhomo-logy) domain. It is thought to be involved in the cross-linking of microtubules and microfilaments.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: GAS2-like protein 1; GAS2-related protein on chromosome 22; growth arrest-specific 2 like 1; Growth arrest-specific protein 2-like 1
基因别名: GAR22; GAS2L1
UniProt ID: (Human) Q99501
Entrez Gene ID: (Human) 10634