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Proteintech
GATA2 Polyclonal Antibody
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产品信息
11103-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GATA2 Fusion Protein Ag1557 (168-467 aa encoded by BC018988)
偶联物
形式
Liquid
浓度
0.36 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: SHLFGFPPT PPKEVSPDPS TTGAASPASS SAGGSAARGE DKDGVKYQVS LTESMKMESG SPLRPGLATM GTQPATHHPI PTYPSYVPAA AHDYSSGLFH PGGFLGGPAS SFTPKQRSKA RSCSEGRECV NCGATATPLW RRDGTGHYLC NACGLYHKMN GQNRPLIKPK RRLTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SNKSKKSKKG AECFEELSKC MQEKSSPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG (168-467 aa encoded by BC018988)
靶标信息
GATA2 (GATA binding protein 2) belongs to the GATA family of transcription factors. GATA proteins play a very important role in signaling pathways controlling proliferation and differentiation of erythroid progenitor cells. There are 6 transcription factors in the GATA family: GATA1 to GATA6. GATA2 is a transcriptional activator regulating endothelin-1 gene expression in endothelial cells. It also appears to be involved in differentiation of other tissue types (uro-genital and nervous) during embryogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Endothelial transcription factor GATA-2; FLJ45948; GATA-binding protein 2; GATA-bindning protein 2; gata2 {ECO:0000312|EMBL:AAK51128.1}; MGC2306
基因别名: DCML; Gata-2; GATA2; IMD21; MONOMAC; NFE1B
UniProt ID: (Human) P23769, (Mouse) O09100, (Rat) Q924Y4
Entrez Gene ID: (Human) 2624, (Mouse) 14461, (Rat) 25159
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
zinc ion binding
C2H2 zinc finger domain binding
DNA binding
sequence-specific DNA binding
metal ion binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
urogenital system development
cell fate determination
neuron migration
embryonic placenta development
transcription, DNA-templated
transcription from RNA polymerase II promoter
phagocytosis
positive regulation of cytosolic calcium ion concentration
heart development
blood coagulation
organ morphogenesis
tissue development
regulation of primitive erythrocyte differentiation
ventral spinal cord interneuron differentiation
cell differentiation in hindbrain
commitment of neuronal cell to specific neuron type in forebrain
central nervous system neuron development
pituitary gland development
response to lipid
somatic stem cell population maintenance
regulation of histone acetylation
eosinophil fate commitment
inner ear morphogenesis
mast cell degranulation
negative regulation of fat cell differentiation
positive regulation of erythrocyte differentiation
negative regulation of macrophage differentiation
positive regulation of megakaryocyte differentiation
positive regulation of neuron differentiation
negative regulation of Notch signaling pathway
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
cell maturation
digestive tract development
homeostasis of number of cells within a tissue
positive regulation of phagocytosis
positive regulation of phagocytosis, engulfment
definitive hemopoiesis
semicircular canal development
negative regulation of fat cell proliferation
GABAergic neuron differentiation
negative regulation of neural precursor cell proliferation
regulation of forebrain neuron differentiation
regulation of transcription, DNA-templated
hemopoiesis
cell differentiation
neuron differentiation
negative regulation of myeloid cell differentiation
neuron fate commitment
