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Proteintech
GBP1 Monoclonal Antibody (2A10E8), CoraLite® Plus 488
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产品信息
CL488-67161
产品规格
种属反应
Human,
Pig,
Rat
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
2A10E8
抗原
Recombinant protein
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
纯化类型
Protein A
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: VHRRKLAQLE KLQDEELDPE FVQQVADFCS YIFSNSKTKT LSGGIQVNGP RLESLVLTYV NAISSGDLPC MENAVLALAQ IENSAAVQKA IAHYEQQMGQ KVQLPTESLQ ELLDLHRDSE REAIEVFIRS SFKDVDHLFQ KELAAQLEKK RDDFCKQNQE ASSDRCSGLL QVIFSPLEEE VKAGIYSKPG GYRLFVQKLQ DLKKKYYEEP RKGIQAEEIL QTYLKSKESM TDAILQTDQT LTEKEKEIEV ERVKAESAQA SAKMLQEMQR KNEQMMEQKE RSYQEHLKQL TEKMENDRVQ LLKEQERTLA LKLQEQEQLL KEGFQKESRI MKNEIQDLQT KMRRRKACTI S
靶标信息
GBP1 or guanlyate binding protein 1 is a 68 kDa GTPase and member of the GTPase1 family of molecules. GBP1 expression is induced by Interferon g as well as other inflammatory cytokines including IL-1a, IL-1b and TNF-a. Induction of GBP1 expression by poly I:C, a prototypical TLR3 ligand, as well as GBP1 expression dependency on NF-kB and IFNa response elements implicate TLR pathway involvement. Inversely proportional expression of GBP1 and MMP-1 as well as other related molecules to adhesion and migration show a clear functional role of GBP1 in suppressing angiogenesis and migration especially of endothelial cells. As a regulatory molecule it is centrally involved in signal transduction of inflammatory and cell migration networks.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GBP-1; GTP-binding protein 1; Guanine nucleotide-binding protein 1; guanylate binding protein 1, interferon-inducible; guanylate binding protein 1, interferon-inducible, 67kDa; Guanylate-binding protein 1; huGBP-1; Interferon-induced guanylate-binding protein 1
基因别名: GBP1
UniProt ID: (Human) P32455
Entrez Gene ID: (Pig) 100151938, (Human) 2633, (Rat) 304266
regulation of calcium-mediated signaling
negative regulation of T cell receptor signaling pathway
defense response to virus
interferon-gamma-mediated signaling pathway
negative regulation of ERK1 and ERK2 cascade
negative regulation of substrate adhesion-dependent cell spreading
negative regulation of interleukin-2 secretion
regulation of protein localization to plasma membrane
negative regulation of protein localization to plasma membrane
metabolic process
cellular response to interferon-beta
defense response to protozoan
adhesion of symbiont to host
defense response to Gram-positive bacterium
cellular response to interferon-gamma
