Invitrogen

GCH1 Polyclonal Antibody

产品信息

PA5-50508

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:200-1:1,000	-
免疫组化（石蜡） (IHC (P))	1:5-1:20	-

产品规格
种属反应	Human
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Synthetic peptide corresponding to a region derived from internal residues of human GTP cyclohydrolase 1
偶联物	Unconjugated
形式	Liquid
浓度	0.5 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.4, with 40% glycerol
内含物	0.05% sodium azide
保存条件	-20°C
RRID	AB_2635961

产品详细信息

The antibody detects endogenous levels of total GCH1 protein.

靶标信息

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: dystonia 14; GTP cyclohydrolase 1; GTP cyclohydrolase I; GTP-CH-I; guanosine 5'-triphosphate cyclohydrolase I

基因别名: DYT14; DYT5; DYT5a; GCH; GCH1; GTP-CH-1; GTPCH1; HPABH4B

UniProt ID: (Human) P30793

Entrez Gene ID: (Human) 2643

分子生物学功能: hydrolase metabolite interconversion enzyme

功能

tetrahydrobiopterin biosynthetic process nitric oxide biosynthetic process regulation of blood pressure regulation of lung blood pressure response to lipopolysaccharide response to interferon-gamma response to tumor necrosis factor 7,8-dihydroneopterin 3'-triphosphate biosynthetic process vasodilation dopamine biosynthetic process pteridine-containing compound biosynthetic process negative regulation of blood pressure tetrahydrofolate biosynthetic process response to pain neuromuscular process controlling posture regulation of nitric-oxide synthase activity positive regulation of nitric-oxide synthase activity protein homooligomerization protein heterooligomerization regulation of removal of superoxide radicals

参与通路

GTP cyclohydrolase I activity calcium ion binding protein binding GTP binding zinc ion binding GTP-dependent protein binding protein homodimerization activity coenzyme binding

GCH1 Polyclonal Antibody

产品信息

PA5-50508

免疫印迹 (WB)

免疫组化（石蜡） (IHC (P))

种属反应

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

RRID

产品详细信息

靶标信息

篇参考文献 (0)

生物信息学

性能保障

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