Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:500-1:3,000 | - |
免疫组化（石蜡） (IHC (P)) |
1:100-1:1,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant protein encompassing a sequence within the center region of human GDF6. The exact sequence is proprietary. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.76 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7, with 20% glycerol |
内含物 |
0.025% Proclin 300 |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2735828 |
Positive Control: U87-MG
Predicted Reactivity: Mouse (91%), Bovine (95%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
GDF6 is a growth differentiation factor (GDFs), which are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. Both GDF6 and GDF7 are closely related to GDF5 which has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate including the eye fields. GDF6 is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. It may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins (BMPs), and control eye development. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BMP-13; Bone morphogenetic protein 13; GDF-6; growth differentiation factor 16; Growth/differentiation factor 16; Growth/differentiation factor 6; Klip-Feil malformation; Klippel-Feil malformation; Klippel-Feil syndrome
基因别名: BMP-13; BMP13; CDMP2; GDF16; GDF6; KFM; KFS; KFS1; KFSL; LCA17; MCOP4; MCOPCB6; SCDO4; SGM1
UniProt ID: (Human) Q6KF10, (Rat) Q6HA10
Entrez Gene ID: (Human) 392255, (Rat) 252834
分子生物学功能:
growth factor
