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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
6-8 µg/mL | - |
免疫组化（石蜡） (IHC (P)) |
5 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Bovine, Chicken, Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Portion of amino acid 280-330 of human Zinc finger protein Gfi-1 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Protein A |
保存液 |
PBS |
内含物 |
0.05% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2540995 |
GFI1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. The Gfi1 protein expression is regulated by the ubiquitin-proteasome system. It is reported that ubiquitin ligase Triad1 interacts with the DNA-binding domain of Gfi-1. Gfi-1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. Deficiency of Gfi-1 causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome in mice.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FLJ94509; growth factor independence-1; growth factor independent 1 transcription repressor; Growth factor independent protein 1; Growth factor independent-1; Zinc finger protein 163; Zinc finger protein Gfi-1
基因别名: AW495828; GFI-1; GFI1; GFI1A; Pal-1; Pal1; SCN2; ZNF163
UniProt ID: (Human) Q99684, (Rat) Q07120, (Mouse) P70338
Entrez Gene ID: (Chicken) 429088, (Bovine) 100139952, (Human) 2672, (Rat) 24388, (Mouse) 14581
