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Invitrogen
GFRAL Polyclonal Antibody
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GFRAL Antibody (PA5-47769) in IHC (P)
Immunohistochemical analysis of GFRAL in immersion fixed paraffin-embedded sections of mouse spinal cord. Samples were incubated with GFRAL polyclonal antibody (Product # PA5-47769) using a dilution of 5 µg/mL for 1 hour at room temperature followed by Anti-Sheep IgG VisUCyte™ HRP Polymer Antibody. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Anti... View More
产品信息
PA5-47769
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
C. elegans,
Mouse
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CHO-derived recombinant mouse GFR alpha-like isoform A Gln20-Gly349
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISA, less than 1% cross-reactivity with recombinant mouse (rm) GFR alpha -3 and rmGFR alpha -4 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: GDNF family receptor alpha-like; GDNF receptor alpha-like
基因别名: AY457637; Gfral; Gral
UniProt ID: (Mouse) Q6SJE0
Entrez Gene ID: (Mouse) 404194
