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Proteintech
GGCX Polyclonal Antibody
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产品信息
16209-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GGCX Fusion Protein Ag9185 (383-758 aa encoded by BC013979)
偶联物
形式
Liquid
浓度
0.22 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: LTQGYNNWT NGLYGYSWDM MVHSRSHQHV KITYRDGRTG ELGYLNPGVF TQSRRWKDHA DMLKQYATCL SRLLPKYNVT EPQIYFDIWV SINDRFQQRI FDPRVDIVQA AWSPFQRTSW VQPLLMDLSP WRAKLQEIKS SLDNHTEVVF IADFPGLHLE NFVSEDLGNT SIQLLQGEVT VELVAEQKNQ TLREGEKMQL PAGEYHKVYT TSPSPSCYMY VYVNTTELAL EQDLAYLQEL KEKVENGSET GPLPPELQPL LEGEVKGGPE PTPLVQTFLR RQQRLQEIER RRNTPFHERF FRFLLRKLYV FRRSFLMTCI SLRNLILGRP SLEQLAQEVT YANLRPFEAV GELNPSNTDS SHSNPPESNP DPVHSEF (383-758 aa encoded by BC013979 )
靶标信息
GGCX (gamma-glutamyl carboxylase), also known as GC or VKCFD1 (Vitamin K-dependent gamma-carboxylase), is a 758 amino acid multi-pass membrane protein. Localized to the membrane of the endoplasmic reticulum, GGCX functions to mediate the vitamin K-dependent carboxylation of glutamate residues on target proteins, thereby producing calcium binding gamma-carboxyglutamate (Gla) residues on these proteins and simultaneously converting vitamin K to vitamin K epoxide. GGCX exists as a monomer and, via its ability to modify glutamate residues, it accomplishes the post-translational changes that are necessary for the activity of all vitamin K-dependent proteins (such as blood coagulation and bone matrix proteins). Defects in the gene encoding GGCX are the cause of combined deficiency of vitamin K-dependent clotting factors 1 (VKCFD1) and PXE-like disorder with multiple coagulation factor deficiency, both of which are characterized by abnormal skin, blood or bone function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FLJ26629; Gamma-glutamyl carboxylase; Peptidyl-glutamate 4-carboxylase; Vitamin K gamma glutamyl carboxylase; Vitamin K-dependent gamma-carboxylase
基因别名: GC; GGCX; VKCFD1
UniProt ID: (Human) P38435, (Rat) O88496, (Mouse) Q9QYC7
Entrez Gene ID: (Human) 2677, (Rat) 81716, (Mouse) 56316
