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产品信息
PA5-55230
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human GGH
偶联物
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2641978
产品详细信息
Immunogen sequence: FDDGDYFPVW GTCLGFEELS LLISGECLLT ATDTVDVAMP LNFTGGQLHS RMFQNFPTEL LLSLAVEPLT ANFHKWSLSV KNFTMNEKLK K
Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 73%.
靶标信息
Gamma-Glutamyl hydrolase (GGH) is a homodimeric protein that catalyzes the cleavage of the gamma-glutamyl chain of folylpoly-gamma-glutamyl substrates and is a central enzyme in folyl and antifolyl poly-gamma-glutamate metabolism. The activities of the baculovirus-expressed enzyme and the enzyme from HL-60 cells were similar on methotrexate polyglutamates. GGH is expressed in a variety of human tumors and correlates with poor prognosis.
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生物信息学
蛋白别名: Conjugase; Gamma-Glu-X carboxypeptidase; Gamma-glutamyl hydrolase; gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); GH
基因别名: GGH; GH
UniProt ID: (Human) Q92820
Entrez Gene ID: (Human) 8836
分子生物学功能:
cysteine protease
