Immunogen sequence: FDDGDYFPVW GTCLGFEELS LLISGECLLT ATDTVDVAMP LNFTGGQLHS RMFQNFPTEL LLSLAVEPLT ANFHKWSLSV KNFTMNEKLK K
Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 73%.
Gamma-Glutamyl hydrolase (GGH) is a homodimeric protein that catalyzes the cleavage of the gamma-glutamyl chain of folylpoly-gamma-glutamyl substrates and is a central enzyme in folyl and antifolyl poly-gamma-glutamate metabolism. The activities of the baculovirus-expressed enzyme and the enzyme from HL-60 cells were similar on methotrexate polyglutamates. GGH is expressed in a variety of human tumors and correlates with poor prognosis.
蛋白别名: Conjugase; Gamma-Glu-X carboxypeptidase; Gamma-glutamyl hydrolase; gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); GH
基因别名: GGH; GH
UniProt ID: (Human) Q92820
Entrez Gene ID: (Human) 8836
分子生物学功能: cysteine protease