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Invitrogen
GITR (TNFRSF18) Monoclonal Antibody (T9P4G4-D7), PerCP
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产品信息
MA5-45911
产品规格
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
T9P4G4-D7
抗原
Synthetic peptide from the C-terminal of Human Tumor Necrosis Factor Receptor Superfamily, Member 18
偶联物
激发/发射光谱
482/675 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
A 1:1,000 dilution of MA5-45911 was sufficient for detection of Tumor Necrosis Factor Receptor Superfamily, Member 18 in 15 µg of Mouse Skeletal Muscle by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects 25 kDa.
靶标信息
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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