Search
Rockland
GITRL Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
图: 1 / 2
GITRL Antibody (600-401-BL0) in ICC/IF
Immunocytochemistry of GITRL antibody. Cell Type: THP-1 cells. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: GITRL antibody at 10 µg/mL for 1 hr at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: GITRL is located in the cell membrane. Staining: GITRL is stained brown with hematoxylin purple nuclear counterstain.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
600-401-BL0
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-GITRL antibody was prepared from whole rabbit serum produced by repeated immunizations with purified recombinant human GITR ligand.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappa-B and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-kappa-B, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kappa-B activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: activation-inducible TNF-related ligand; AITR ligand; GITR ligand; GITRLigand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand; glucocorticoid-induced-tumor necrosis factor receptor ligand; RP1-15D23.1; TNF alpha family member; GITR ligand; GITRL; TNF superfamily member 18; TNF superfamily member 18; MGL; transmembrane type II protein; tumor necrosis factor (ligand) superfamily, member 18; tumor necrosis factor ligand 2A; tumor necrosis factor superfamily member 18; type II membrane protein; unnamed protein product
基因别名: AITRL; GITRL; hGITRL; TL6; TNLG2A
UniProt ID: (Human) Q9UNG2, (Mouse) Q7TS55
Entrez Gene ID: (Human) 8995, (Mouse) 240873
T cell proliferation involved in immune response
positive regulation of leukocyte migration
immune response
signal transduction
cell-cell signaling
positive regulation of macrophage chemotaxis
tumor necrosis factor-mediated signaling pathway
regulation of T cell proliferation
positive regulation of tyrosine phosphorylation of STAT protein
negative regulation of apoptotic process
regulation of protein complex assembly
positive regulation of cell adhesion
positive regulation of inflammatory response
positive regulation of monocyte chemotaxis
negative regulation of T-helper 17 cell lineage commitment
regulation of dendritic cell chemotaxis
regulation of interferon-gamma production
regulation of interleukin-6 production
regulation of tumor necrosis factor production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
activated CD4-positive, alpha-beta T cell proliferation
regulation of monocyte chemotactic protein-1 production
regulation of CD40 signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
