Invitrogen

GLI2 Recombinant Superclonal™ Antibody (9HCLC)

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GLI2 Recombinant Superclonal™ Antibody (9HCLC)

产品信息

711045

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1-2 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

Expi293

分类

Recombinant Superclonal

类型

Antibody

克隆号

9HCLC

抗原

Protein corresponding to Human GLI2 (aa 1-332)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.2

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2633108

产品详细信息

This antibody is predicted to react with Monkey, Pig, Bovine and Rabbit

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.

靶标信息

Gli-2 belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: GLI family zinc finger protein 2; GLI-Kruppel family member GLI2; glioma-associated oncogene family zinc finger 2; oncogene GLI2; Tax helper protein; tax helper protein 1; tax helper protein 2; tax-responsive element-2 holding protein; tax-responsive element-25-bp sequence binding protein; Zinc finger protein GLI2

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基因别名: AW546128; CJS; GLI2; HPE9; PHS2; THP; THP1; THP2

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UniProt ID: (Human) P10070, (Mouse) Q0VGT2

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Entrez Gene ID: (Human) 2736, (Rat) 304729, (Mouse) 14633

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功能
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding sequence-specific DNA binding molecular_function DNA binding transcription regulatory region DNA binding nucleic acid binding metal ion binding DNA-binding transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter skeletal system development in utero embryonic development kidney development chondrocyte differentiation osteoblast development transcription from RNA polymerase II promoter smoothened signaling pathway pattern specification process axon guidance ventral midline development hindgut morphogenesis heart development cell proliferation regulation of smoothened signaling pathway response to mechanical stimulus anterior/posterior pattern specification proximal/distal pattern formation floor plate formation spinal cord dorsal/ventral patterning ventral spinal cord development cerebellar cortex morphogenesis smoothened signaling pathway involved in ventral spinal cord interneuron specification smoothened signaling pathway involved in spinal cord motor neuron cell fate specification smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation spinal cord ventral commissure morphogenesis pituitary gland development lung development mammary gland development hindbrain development negative regulation of chondrocyte differentiation positive regulation of T cell differentiation in thymus tube development odontogenesis of dentin-containing tooth embryonic digit morphogenesis negative regulation of apoptotic process positive regulation of neuron differentiation positive regulation of DNA replication positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic digestive tract development developmental growth neuron development branching morphogenesis of an epithelial tube notochord regression prostatic bud formation mammary gland duct morphogenesis smoothened signaling pathway involved in dorsal/ventral neural tube patterning cellular response to organic cyclic compound cochlea morphogenesis osteoblast differentiation morphogenesis of an epithelium positive regulation of cell proliferation epidermal cell differentiation dorsal/ventral pattern formation spinal cord motor neuron differentiation dorsal/ventral neural tube patterning neural tube development cell differentiation anatomical structure formation involved in morphogenesis anatomical structure development head development cellular response to virus transcription, DNA-templated regulation of transcription, DNA-templated
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