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Invitrogen
GLRA1 Polyclonal Antibody
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产品信息
PA1-12752
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the N-terminal of the alpha1-subunit of glycine receptor.
偶联物
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
In Western blot, this antibody recognizes a ~48 kD band corresponding to the alpha-1 or alpha-2 subunits of the glycine receptor; it does not recognize other glycine receptor subunits. A suggested positive control for this product is rat spinal cord lysate.
Reconstitute using 100 µL of PBS. Once reconstituted, aliquot and store at -20°C.
靶标信息
GLRA1 is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in GLRA1 are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found for GLRA1. Glycine receptors (GlyR) that include GLRA1 are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. GLRA1 are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1 and Hyperekplexia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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