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Proteintech
GLUD1 Monoclonal Antibody (4G10D3)
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产品信息
67026-1-IG
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
4G10D3
抗原
GLUD1 Fusion Protein Ag6179
偶联物
形式
Liquid
浓度
1000 µg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Aliquoting is unnecessary for -20°C storage.
靶标信息
Glutamate dehydrogenase, GluD1, is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.
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生物信息学
蛋白别名: epididymis tissue sperm binding protein Li 18mP; GDH 1; glutamate dehydrogenase (NAD(P)+); Glutamate dehydrogenase 1, mitochondrial; Memory-related gene 2 protein; MRG-2
基因别名: Ac2-281; AI118167; GDH; Gdh-X; GDH1; GLUD; GLUD1; Gludeha; Gludl; MRG-2
UniProt ID: (Human) P00367, (Mouse) P26443, (Rat) P10860
Entrez Gene ID: (Human) 2746, (Mouse) 14661, (Rat) 24399
glutamate biosynthetic process
glutamate catabolic process
glutamine metabolic process
cellular amino acid biosynthetic process
substantia nigra development
positive regulation of insulin secretion
oxidation-reduction process
tricarboxylic acid metabolic process
cellular amino acid metabolic process
response to aluminum ion
long-term memory
