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Invitrogen
GNA11 Polyclonal Antibody
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GNA11 Antibody (PA5-119130) in IHC (P)
Immunohistochemistry analysis of GNA11 in paraffin-embedded Human Cerebellum tissue. Samples were incubated with polyclonal antibody (Product # PA5-119130) at a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.
产品信息
PA5-119130
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein G Protein Alpha 11. The antigen corresponds to amino acid range 1-359 of the target protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography, Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Gα subunits have been classified into four families, Gα(s), Gα(i/o), Gα(q) and Gα(12), based on structural and functional similarities (1,2). Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Gα with receptors and abolishes ligand-induced IP3 formation (3).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G alpha-11; G-protein subunit alpha-11; Gq class; guanine nucleotide binding protein (G protein), alpha 11 (Gq class); guanine nucleotide regulatory protein G alpha 11; guanine nucleotide-binding protein alpha 11 subunit; Guanine nucleotide-binding protein G(y) subunit alpha; Guanine nucleotide-binding protein subunit alpha-11
基因别名: FBH; FBH2; FHH2; GA11; GNA-11; GNA11; HHC2; HYPOC2
UniProt ID: (Human) P29992, (Rat) Q9JID2
Entrez Gene ID: (Human) 2767, (Rat) 81662
skeletal system development
action potential
signal transduction
G-protein coupled acetylcholine receptor signaling pathway
heart development
phototransduction, visible light
entrainment of circadian clock
platelet activation
regulation of melanocyte differentiation
developmental pigmentation
phospholipase C-activating dopamine receptor signaling pathway
cellular response to pH
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
glutamate receptor signaling pathway
metabolic process
