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Invitrogen
GNAI1/GNAI2/GNAI3 Recombinant Rabbit Monoclonal Antibody (HL2093)
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GNAI1/GNAI2/GNAI3 Antibody (MA5-50379) in WB
Western Blot analysis of GNAI1/GNAI2/GNAI3 using GNAI1/GNAI2/GNAI3 Recombinant Monoclonal Antibody (Product # MA5-50379) in A431 (30 μg) and HeLa (30 μg) whole cell extracts at a dilution of 1:1,000. Extracts were separated by 10% SDS-PAGE. An HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-50379
产品规格
种属反应
Human,
Mouse,
Rat,
Zebrafish
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2093
抗原
Recombinant fragment of human GNAI3.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
GNAI1/GNAI2/GNAI3 are genes that encode for the G protein alpha inhibiting activity subunit. These proteins play a crucial role in signal transduction pathways, particularly in the inhibition of adenylyl cyclase. They are involved in various physiological processes, including neurotransmitter release, hormone secretion, and regulation of smooth muscle contraction. Mutations in these genes have been associated with various diseases, including hypoparathyroidism, pituitary adenoma, and cardiovascular disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Adenylate cyclase-inhibiting G alpha protein; G alpha inhibitory type 2 (a); G alpha inhibitory type 2 (b); G(i) alpha-3; Galpha i1a; Galpha i3; GTP-binding protein (G-alpha-i2); guanine nucleotide binding protein (G protein), alpha inhibiting 1; guanine nucleotide binding protein (G protein), alpha inhibiting 2; guanine nucleotide binding protein (G protein), alpha inhibiting 3; guanine nucleotide binding protein, alpha inhibiting 1; guanine nucleotide binding protein, alpha inhibiting 2; guanine nucleotide binding protein, alpha inhibiting 3; Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3; Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding protein G(i) subunit alpha-3; guanine nucleotide-binding protein G(i), alpha-1 subunit; guanine nucleotide-binding protein G(i), alpha-2 subunit; guanine nucleotide-binding protein G(k) subunit alpha; HG1B/HG1C/HG1A
基因别名: AI158965; AU046200; AW537698; BPGTPB; C76432; Galphai2; Galphai3; Gia; Gialpha1; GIP3A; Gnai-1; Gnai-2; Gnai-3; GNAI1; GNAI2; GNAI2B; GNAI3; zgc:63957
UniProt ID: (Rat) P10824, (Mouse) B2RSH2, (Rat) P04897, (Mouse) P08752, (Rat) P08753, (Mouse) Q9DC51
Entrez Gene ID: (Rat) 25686, (Mouse) 14677, (Rat) 81664, (Mouse) 14678, (Rat) 25643, (Mouse) 14679, (Zebrafish) 393946, (Zebrafish) 100006888
GTPase activity
signal transducer activity
protein binding
GTP binding
GDP binding
G-protein beta/gamma-subunit complex binding
G-protein coupled serotonin receptor binding
GTPase activating protein binding
metal ion binding
nucleotide binding
guanyl nucleotide binding
G-protein coupled receptor binding
protein domain specific binding
heterotrimeric G-protein
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
metabolic process
negative regulation of synaptic transmission
cell division
cell cycle
signal transduction
activation of MAPKK activity
adenosine receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
gamma-aminobutyric acid signaling pathway
G-protein coupled glutamate receptor signaling pathway
regulation of heart contraction
cell proliferation
positive regulation of cell proliferation
intracellular signal transduction
regulation of calcium ion transport
vesicle fusion
negative regulation of secretion
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