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Agrisera
GPA1/Guanine nucleotide-binding protein subunit alpha 1 Polyclonal Antibody
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GPA1/Guanine nucleotide-binding protein subunit alpha 1 Antibody (AS12-2370) in WB
Immunodetection of GPA 1 (alpha subunit of heterotrimeric G protein). Microsomes were affinity purified to isolate palmitoylated proteins using the acyl biotin exchange method 1. Proteins were separated by SDS-PAGE and immunodetected with anti-GPA 1. GPA 1 is expected to be modified by S-acylation and was enriched in the affinity-purified fraction. 1. Wan, J., Roth, A. F., Bailey, A. O. & Davis, N. G. Palmi... View More
产品信息
AS12-2370
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated synthetic peptide derived from Arabidopsis thaliana GPA1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
靶标信息
GPA1 encodes the alpha subunit of a heterotrimeric G protein that localizes predominantly to the cytoplasmic face of the plasma membrane, consistent with an N-terminal region that is sufficient for membrane targeting, positioning the protein to couple cell-surface pheromone receptors to intracellular signaling. The gene produces a soluble, peripheral membrane GTP-binding protein of 472 amino acids with the conserved G-alpha fold and hallmark nucleotide-binding/hydrolysis motifs that support cycling between GDP-bound inactive and GTP-bound active conformations. Functionally, Gpa1 is a central regulator of the yeast mating pheromone response: in its inactive state it restrains pathway activation by sequestering the Gbeta-gamma complex, while activation-state changes enable downstream signaling that shapes mating-associated cell cycle arrest, polarity, and differentiation, including evidence that activated Gpa1 can transmit signals through an RNA-binding effector (Scp160) and contributes to spatial control of pathway outputs at the cell cortex and endomembrane system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARABIDOPSIS THALIANA G PROTEIN ALPHA SUBUNIT 1; ATGPA1; G PROTEIN ALPHA SUBUNIT; G PROTEIN ALPHA SUBUNIT 1; GP ALPHA 1; T1D16.6; T1D16_6
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