Proteintech

GPAM Polyclonal Antibody

Name: GPAM Polyclonal Antibody
Brand: Proteintech
SKU: 12454-1-AP

查看其他6个GPAM抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)

GPAM Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GPAM Antibody (12454-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 12454-1-AP (GPAM antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

GPAM Antibody in Immunoprecipitation (IP)

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Immunogen image

Immunogen Image GPAM Polyclonal Antibody

产品信息

12454-1-AP

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500

酶联免疫吸附实验 (ELISA)

Assay-dependent

免疫沉淀 (IP)

0.5-4.0 µg for 1.0-3.0 mg of total protein lysate

产品规格

种属反应

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

GPAM fusion protein Ag3120

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.75 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

产品详细信息

Immunogen sequence: SCAIMSTHIV ACLLLYRHRQ GIDLSTLVED FFVMKEEVLA RDFDLGFSGN SEDVVMHAIQ LLGNCVTITH TSRNDEFFIT PSTTVPSVFE LNFYSNGVLH VFIMEAIIAC SLYAVLNKRG LGGPTSTPPN LISQEQLVRK AASLCYLLSN EGTISLPCQT FYQVCHETVG KFIQYGILTV AEHDDQEDIS PSLAEQQWDK KLPEPLSWRS DEEDEDSDFG EEQRDCYLKV SQSKEHQQFI TFLQRLLGPL LEAYSSAAIF VHNFSGPVPE PEYLQKLHKY LITRTERNVA VYAESATYCL VKNAVKMFKD IGVFKETKQK RVSVLELSST FLPQCNRQKL LEYILSFVVL

靶标信息

Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.

仅用于科研。不用于诊断过程。未经明确授权不得转售。