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Invitrogen
GPNMB Polyclonal Antibody
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GPNMB Antibody (PA5-89716) in WB
Western blot analysis of GPNMB in SK-MEL-28 cells. Samples were incubated with GPNMB Polyclonal antibody (Product # PA5-89716) using a dilution of 1:2,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
PA5-89716
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment)
偶联物
形式
Liquid
浓度
1.85 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: A-549, K-562, U-87MG, Mouse brain, Mouse liver, Rat brain, Rat liver; Cellular Location: Cell membrane, Melanosome, Single-pass type I membrane protein
Immunogen sequence: KRFHDVLGNE RPSAYMREHN QLNGWSSDEN DWNEKLYPVW KRGDMRWKNS WKGGRVQAVL TSDSPALVGS NITFAVNLIF PRCQKEDANG NIVYEKNCRN EAGLSADPYV YNWTAWSEDS DGENGTGQSH HNVFPDGKPF PHHPGWRRWN FIYVFHTLGQ YFQKLGRCSV RVSVNTANVT LGPQLMEVTV YRRHGRAYVP IAQVKDVYVV TDQIPVFVTM FQKNDRNSSD ETFLKDLPIM FDVLIHDPSH FLNYSTINYK WSFGDNTGLF VSTNHTVNHT YVLNGTFSLN LTVKAAAPGP CPPPPPPPRP SKPTPSLATT LKSYDSNTPG PAGDNPLELS RIPDENCQIN RYGHFQATIT IVEGILEVNI IQMTDVLMPV PWPESSLIDF VVTCQGSIPT EVCTIISDPT CEITQNTVCS PVDVDEMCLL TVRRTFNGSG TYCVNLTLGD DTSLALTSTL ISVP
靶标信息
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DC-HIL; dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; Dendritic cell-associated transmembrane protein; glycoprotein (transmembrane) nmb; glycoprotein nmb-like protein; glycoprotein nonmetastatic melanoma protein B; hematopoietic growth factor inducible neurokinin-1; Hematopoietic growth factor inducible neurokinin-1 type; iris pigment dispersion; Osteoactivin; transmembrane glycoprotein HGFIN; Transmembrane glycoprotein NMB
基因别名: DC-HIL; Dchil; GPNMB; HGFIN; ipd; NMB; UNQ1725/PRO9925
UniProt ID: (Human) Q14956, (Mouse) Q99P91
Entrez Gene ID: (Human) 10457, (Rat) 113955, (Mouse) 93695
