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This antibody detects endogenous protein at a molecular weight of 333 kDa.
Purity is >95% by SDS-PAGE.
G protein-coupled receptors(GPRs or GPCRs), also known asseven transmembrane receptors, heptahelical receptors or 7TMreceptors, aremembers of the largest protein family and play a role in many differentstimulus-response pathways. G protein-coupled receptors mediate extracellularsignals into intracellularsignals(G protein activation). Theyrespond to awide variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides. GPR proteins are usuallyintegralseven passmembrane proteins with some conserved amino acid regions. GPR112 (G protein-coupled receptor 112) is a 3,080 amino acid multi-pass membrane protein that belongsto the G-protein coupled receptor 2 family and LN-TM7 subfamily. Localizing to cell membrane, GPR112 is highly expressed in normal enterochromaffin cells, aswell as neuroendocrine and primarylivercarcinoma. GPR112 contains one GPS domain andmayfunction as an orphan receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Adhesion G-protein coupled receptor G4; G protein-coupled receptor 112; G-protein coupled receptor 112; probable G-protein coupled receptor 112
基因别名: ADGRG4; Gm367; GPR112; PGR17; RP1-299I16
UniProt ID: (Human) Q8IZF6
Entrez Gene ID: (Human) 139378, (Mouse) 236798
分子生物学功能:
G-protein coupled receptor