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Invitrogen
GPR68 Polyclonal Antibody
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产品信息
PA1-24513
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, KLH conjugated. Sequence identity/similarity to Mouse: 95/95%.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
PA1-24513 detects G Protein-Coupled Receptor OGR1/GPR68 in human samples.
PA1-24513 has been successfully used in immunocytochemistry procedures.
The PA1-24513 immunogen is a synthetic peptide, KLH conjugated. Sequence identity/similarity to Mouse: 95/95%.
靶标信息
GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It represents an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or CA2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also found to serve as a tumor suppressor in prostate cancer. Mutations to the gene result in amelogenesis imperfecta, hypomaturation type 2A6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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