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Invitrogen
GPRC5D/CD3 (Forimtamig Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA5-54897
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1, kappa/IgG1, lambda
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Recombinant Human GPRC5D and CD3E.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Compatible with Direct ELISA
靶标信息
GPRC5D is an orphan G protein-coupled receptor belonging to the class C GPCR family. Its physiological ligand and normal biological function are not fully defined. Under normal conditions, GPRC5D expression is limited, with highest levels reported in keratinized tissues such as hair follicles. In oncology, GPRC5D is highly expressed on malignant plasma cells in multiple myeloma, with minimal expression in most other normal tissues. This restricted expression profile has made GPRC5D an attractive therapeutic target for antibody-based therapies and T cell-redirecting approaches, including bispecific antibodies and CAR T cell therapies, in the treatment of relapsed or refractory multiple myeloma.
The CD3 complex, composed of gamma, delta, epsilon, and zeta subunits, is essential for the assembly, trafficking, and surface expression of the T cell receptor (TCR) complex. These subunits are structurally related members of the immunoglobulin superfamily and are encoded by closely linked genes on human chromosome 11. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells, but not on B or NK cells. The CD3 subunits play a crucial role in transducing antigen-recognition signals into the cytoplasm of T cells. The cytoplasmic tails of CD3 subunits contain a double tyrosine-based motif that associates with cytoplasmic signal transduction molecules, mediating T cell activation through the TCR. Crosslinking of the TCR initiates intracellular biochemical pathways that result in cellular activation, proliferation, and potentially growth arrest and cell survival. CD3 is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes, and Purkinje cells in the cerebellum. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency, highlighting its importance in immune function and regulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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