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Participates in the organization of endoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: GRAM domain containing 2; GRAM domain-containing protein 2; GRAM domain-containing protein 2A
基因别名: BC064463; GRAMD2; GRAMD2A; RGD1564007
UniProt ID: (Human) Q8IUY3, (Mouse) Q3V3G7
Entrez Gene ID: (Human) 196996, (Rat) 300761, (Mouse) 546134