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This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: GSK3-beta interaction protein; GSK3B-interacting protein; GSK3beta interaction protein; GSKIP; MGC4945
基因别名: 4933433P14Rik; C14orf129; GSKIP; HSPC210; RGD1308470
UniProt ID: (Human) Q9P0R6, (Mouse) Q8BGR8, (Rat) Q5PPI3
Entrez Gene ID: (Human) 51527, (Mouse) 66787, (Rat) 362778