FIGURE: 1 / 2
Peptide Sequence: PQVSQTNSNV ESVLSGSASM AQNLHDESLS TSPHGALHQH VTDIQLHILK NRMYGCDSVK QPRNIEEPSN IPVSEKDSNS QVDLSIRVTD DDIGEIIQ
The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
Protein Aliases: CXCDC1; General transcription factor II A, 1-like factor; general transcription factor IIA 1 like; general transcription factor IIA 1-like; general transcription factor IIA, 1-like; GTF2A1-like factor; KIAA2037; testis secretory sperm-binding protein Li 230m; TFIIA large subunit isoform ALF; TFIIA-alpha and beta-like factor; TFIIA-alpha/beta-like factor
Gene Aliases: ALF; GTF2A1L; GTF2A1LF
UniProt ID: (Human) Q9UNN4
Entrez Gene ID: (Human) 11036
Molecular Function: general transcription factor