The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995).
蛋白别名: general transcription factor IIA 2; General transcription factor IIA subunit 2; general transcription factor IIA, 2 (12kD subunit); general transcription factor IIA, 2, 12kDa; TFIIA gamma subunit; TFIIA p12 subunit; TFIIA-12; TFIIA-gamma; Transcription initiation factor IIA gamma chain; Transcription initiation factor IIA subunit 2
基因别名: GTF2A2; HsT18745; T18745; TF2A2; TFIIA; TFIIA-12; TFIIA-gamma; Tfiia2; TFIIAS; TfIIg
分子生物学功能: general transcription factor