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Invitrogen
GTF2H3 Polyclonal Antibody
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GTF2H3 Antibody (PA5-96603) in WB
Western blot analysis of GTF2H3 in extracts of various cell lines. Samples were incubated with GTF2H3 Polyclonal antibody (Product # PA5-96603) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-96603
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-308 of human GTF2H3 (NP_0015072)
偶联物
形式
Liquid
浓度
2.19 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MVSDEDELNL LVIVVDANPI WWGKQALKES QFTLSKCIDA VMVLGNSHLF MNRSNKLAVI ASHIQESRFL YPGKNGRLGD FFGDPGNPPE FNPSGSKDGK YELLTSANEV IVEEIKDLMT KSDIKGQHTE TLLAGSLAKA LCYIHRMNKE VKDNQEMKSR ILVIKAAEDS ALQYMNFMNV IFAAQKQNIL IDACVLDSDS GLLQQACDIT GGLYLKVPQM PSLLQYLLWV FLPDQDQRSQ LILPPPVHVD YRAACFCHRN LIEIGYVCSV CLSIFCNFSP ICTTCETAFK ISLPPVLKAK KKKLKVSA; Positive Samples: HL-60, HT-29, MCF-7, Jurkat; Cellular Location: Nucleus
靶标信息
GTF2H3 interacts with HIV-1 Tat as a component of the HIV-1 transcription pre-initiation complex, but is released from the elongation complex which includes P-TEFb. It synergizes with HIV-1 Tat to induce transcription elongation from the HIV-1 LTR promoter.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Basic transcription factor 2 34 kDa subunit; BTF2 p34; BTF2-p34; General transcription factor IIH polypeptide 3; General transcription factor IIH subunit 3; general transcription factor IIH, polypeptide 3, 34kDa; TFIIH basal transcription factor complex p34 subunit
基因别名: 34kDa; 5033417D07Rik; BTF2; BTF2 p34; C730029A10; D5Ertd679e; GTF2H3; P34; TFB4; TFIIH
UniProt ID: (Human) Q13889, (Mouse) Q8VD76
Entrez Gene ID: (Human) 2967, (Mouse) 209357
damaged DNA binding
transcription factor activity, sequence-specific DNA binding
protein kinase activity
protein binding
DNA-dependent ATPase activity
translation factor activity, RNA binding
RNA polymerase II carboxy-terminal domain kinase activity
metal ion binding
protein N-terminus binding
general transcription factor
RNA metabolism protein
nucleic acid metabolism protein
nucleotide-excision repair, DNA duplex unwinding
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
translation
nucleotide-excision repair, DNA incision
phosphorylation of RNA polymerase II C-terminal domain
global genome nucleotide-excision repair
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
