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NeoBiotechnologies
Galectin-9 (LGALS9) (Marker of T-Cell Exhaustion) Monoclonal Antibody (LGALS9/7689)
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产品信息
3965-MSM5-P1ABX
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2, kappa
分类
Monoclonal
类型
Antibody
克隆号
LGALS9/7689
抗原
Recombinant fragment (around aa 200-355) of human LGALS9 protein (exact sequence is proprietary).
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product cellular localization: Cytoplasm.
Positive control: Human lung, liver, breast or kidney.
Tissue specificity: Accentuated expression in liver and thymus of embryo, detected in embryonic heart, brain, lung, liver, and kidney. Highly expressed in adult thymus, small intestine, and liver, and to a lesser extent in lung, kidney, spleen, cardiac, and skeletal muscle. Barely detectable in brain and reticulocyte. Expressed in placenta, uterus and decidua during pregnancy (PubMed:23242525). Expressed in CD4+ T-cells with higher levels in iTreg cells than other T-cell types and sustained high levels throughout iTreg cell differentiation (at protein level) (PubMed:25065622). Expressed in myeloid cells in lung (PubMed:20937702). Constitutively expressed in microglia (PubMed:25158758). Isoform 1 is expressed exclusively in the small intestine. Isoform 2 expression in decidua increases in pathological pregnancy from gestation day 7.5 to 13.5 and it is higher than in normal pregnancy (PubMed:23242525). Isoform 3 expression in decidua is higher in normal pregnancy than in pathological pregnancy (PubMed:23242525).
靶标信息
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H and RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ecalectin; Gal-9; Gal9; Galectin-9; Galectin9; HOM HD 21; lectin, galactoside binding soluble 9; lectin, galactoside-binding, soluble, 9; Tumor antigen HOM-HD-21; urate transporter/channel protein
基因别名: HUAT; LGALS9; LGALS9A
UniProt ID: (Human) O00182
Entrez Gene ID: (Human) 3965
natural killer cell tolerance induction
chemotaxis
inflammatory response
female pregnancy
positive regulation of gene expression
negative regulation of gene expression
response to lipopolysaccharide
regulation of interleukin-4 production
regulation of interleukin-5 production
negative regulation of chemokine production
negative regulation of interferon-gamma production
negative regulation of tumor necrosis factor production
positive regulation of interleukin-4 production
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
toll-like receptor 2 signaling pathway
toll-like receptor 4 signaling pathway
p38MAPK cascade
positive regulation of NF-kappaB import into nucleus
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of mast cell degranulation
negative regulation of natural killer cell mediated cytotoxicity
negative regulation of activated T cell proliferation
positive regulation of viral entry into host cell
positive regulation of interleukin-1 beta secretion
positive regulation of NF-kappaB transcription factor activity
maternal process involved in female pregnancy
positive regulation of activated T cell autonomous cell death
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
response to interleukin-1
cellular response to interferon-gamma
positive regulation of transforming growth factor beta production
positive regulation of monocyte chemotactic protein-1 production
mature conventional dendritic cell differentiation
cellular response to virus
regulation of p38MAPK cascade
positive regulation of interferon-gamma secretion
positive regulation of tumor necrosis factor secretion
positive regulation of interleukin-8 secretion
positive regulation of dendritic cell chemotaxis
negative regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of interleukin-13 secretion
positive regulation of dendritic cell apoptotic process
positive regulation of interleukin-6 secretion
positive regulation of interleukin-10 secretion
positive regulation of interleukin-12 secretion
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
positive regulation of dendritic cell differentiation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
