The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Gemin 3 is a member of the DEAD box protein family which are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. DEAD box proteins such as Gemin 3 are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of DEAD box family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Gemin 3 has an ATPase activity and a component of the survival of motor neurons (SMN) complex. The Gemin 3 protein may play a catalytic role in the function of the SMN complex on RNPs. Diseases associated with Gemin 3 protein dysfunction include spinal muscular dystrophy and muscular atrophy.
蛋白别名: Component of gems 3; DDX 20; DEAD (Asp-Glu-Ala-Asp) box polypeptide 20; DEAD box protein 20; DEAD box protein DP 103; DEAD-box protein DP103; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD/H BOX 20; DKFZP434H052; DP 103; Gemin-3; Probable ATP-dependent RNA helicase DDX20; Regulator of steroidogenic factor 1; ROSF-1; SMN-interacting protein
基因别名: DDX20; DP103; GEMIN3