PA1-1046 detects recombinant human ghrelin. This antibody detect both the octanoylated and non-octanoylated forms of ghrelin.
PA1-1046 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~3 kDa protein representing recombinant human ghrelin.
The PA1-1046 immunogen is a synthetic peptide corresponding to residues G(1) S S F L S P E H Q R V Q Q R K E S K K P P A K L P Q R(28) of human GHRL.
GHRL encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an the ligand for the growth hormone secretagogue receptor type 1 and is involved in regulating growth hormone release. Ghrelin has an appeptite-stimulating effect and induces adiposity and stimulates gastric acid secretion. Obestatin may be the ligand for the orphan G protein-coupled receptor GPR39 and is involved in satiety and can have an appetite-reducing effect resulting in decreased food intake.
蛋白别名: AMCBX1; Appetite-regulating hormone; FIP3; Fip3p; Ghrelin; ghrelin 27; ghrelin 28; ghrelin, growth hormone secretagogue receptor ligand; Ghrelin-27; Ghrelin-28; ghrelin/obestatin; ghrelin/obestatin preprohormone; Growth hormone secretagogue; Growth hormone-releasing peptide; IKK-gamma; In2c-preproghrelin; IP1; IP2; IPD2; Motilin-related peptide; Obestatin; OTTHUMP00000207794; OTTHUMP00000207795; OTTHUMP00000207796; OTTHUMP00000207798; prepro-appetite regulatory hormone; preproghrelin; Protein M46
基因别名: GHRL; MTLRP; UNQ524/PRO1066
UniProt ID: (Human) Q9UBU3
Entrez Gene ID: (Human) 51738
分子生物学功能: peptide hormone