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AbboMax
GluR6/7 Polyclonal Antibody
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GluR6/7 Antibody (500-2934) in IHC (P)
Immunohistochemistry: Human brain tissue (FFPE) stained with Anti-GluR6/7 antibody (Cat# 500-2934) at 1:50 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
产品信息
500-2934
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide derived from C-terminus of Glutamate receptor 6/7 Protein
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with proprietary stabilizer
内含物
0.01% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive control: Brain
Cellular location: Cytoplasmic, Membrane.
靶标信息
Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: ionotropic receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subunits (GluR1-7, NMDA1-3, KAI-2), which comprise ligand-gated calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors, which when activated can activate phopholipases or adenylylcyclase, depending on the neuron.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bA487F5.1; dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7)); EAA4; EAA5; Excitatory amino acid receptor 4; Excitatory amino acid receptor 5; GluK2; GluK3; gluR beta-2; GluR-6; GluR-7; glutamate receptor; Glutamate receptor 6; Glutamate receptor 7; glutamate receptor beta-2; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; Glutamate receptor ionotropic, kainate 2; Glutamate receptor ionotropic, kainate 3; glutamate receptor subunit kainate subtype; glutamate receptor, ionotropic kainate 2; glutamate receptor, ionotropic, kainate 2; glutamate receptor, ionotropic, kainate 3
基因别名: 9630027E11; AW124492; EAA4; EAA5; GLR6; GLR7; GluK2; GluK3; GLUK6; Glur-6; Glur-7; GLUR6; GLUR7; GluR7-3; GluR7a; Glurbeta2; GRIK2; GRIK3; MRT6
UniProt ID: (Human) D7RWZ4, (Human) Q13003, (Rat) P42260, (Rat) P42264, (Mouse) B1AS29
Entrez Gene ID: (Human) 2898, (Human) 2899, (Rat) 54257, (Mouse) 14806, (Rat) 298521, (Mouse) 14807
extracellular-glutamate-gated ion channel activity
ligand-gated ion channel activity
kainate selective glutamate receptor activity
PDZ domain binding
ubiquitin conjugating enzyme binding
ubiquitin protein ligase binding
protein homodimerization activity
adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
G-protein coupled receptor binding
ionotropic glutamate receptor activity
glutamate receptor activity
protein binding
identical protein binding
receptor activity
ion channel activity
transmembrane signal receptor
behavioral fear response
transport
cellular calcium ion homeostasis
intracellular protein transport
glutamate receptor signaling pathway
chemical synaptic transmission
neuronal action potential
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
receptor clustering
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
regulation of JNK cascade
regulation of long-term neuronal synaptic plasticity
regulation of short-term neuronal synaptic plasticity
modulation of synaptic transmission
positive regulation of synaptic transmission
neuron apoptotic process
negative regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
inhibitory postsynaptic potential
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
regulation of membrane potential
signal transduction
ion transport
