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Rockland
Glucagon Monoclonal Antibody (K79bB10)
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Glucagon Antibody (200-301-P38) in IHC (P)
Immunofluorescence analysis of Glucagon using anti-Glucagon antibody. Glucagon was detected in a paraffin-embedded section of mouse pancreas tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 5 μg/mL mouse anti-Glucagon Antibody overnight at 4°C. DyLight®594 ... View More
产品信息
200-301-P38
产品规格
种属反应
Human,
Mouse,
Rabbit,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
K79bB10
抗原
Glucagon antibody was produced in mice by repeated immunizations with polymerized porcine glucagon.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
1.2% sodium acetate with 2mg BSA
内含物
0.01% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Glucagon is a 29-residue polypeptide hormone (MW 3482), produced in the pancreas. A related hormone, enteroglucagon (or oxyntomodulin), which is produced in the mucosa of the small and large intestine, consists of the 29 amino acid sequence of pancreatic glucagon extended by 8 additional residues at the C-terminus. The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis, and ketogensis, which are antagonistic effects to those of insulin action, thus leading to increased blood glucose levels. Immunocytochemical studies have revealed the presence of pancreatic glucagon inside the A or alpha cells, which constitute 15-20% of the islet cell population. These cells are located preferentially at the periphery of the human pancreatic islets. Pathological manifestations of the glucagon-type peptide residue almost exclusively with the exsistence of tumors or glucagonomas, as no states of glucagon-cell deficiency or hyperplasia have been identified. Glucagon-specific antibodies would prove useful as a cell and tumor markers applying immunohistochemical techniques, and as an analytical tool in qualification of the hormone.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: glicentin-related polypeptide; GLP1/2; glucagon; glucagon-like peptide 1; glucagon-like peptide 2; glucagon-like peptide-1; IL12p35; IL12P40; OXY; preproglucagon; Pro-glucagon
基因别名: GCG; GLP-1; GLP1; GLP2; Glu; GRPP; PPG
UniProt ID: (Human) P01275, (Mouse) P55095
Entrez Gene ID: (Rabbit) 100341777, (Human) 2641, (Mouse) 14526, (Rat) 24952
regulation of carbohydrate metabolic process
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
protein kinase A signaling
positive regulation of peptidyl-threonine phosphorylation
regulation of lipid metabolic process
protein metabolic process
positive regulation of cAMP biosynthetic process
positive regulation of protein binding
negative regulation of appetite
positive regulation of peptidyl-serine phosphorylation
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
response to starvation
negative regulation of apoptotic process
positive regulation of protein kinase activity
regulation of insulin secretion
positive regulation of histone H3-K4 methylation
positive regulation of ERK1 and ERK2 cascade
positive regulation of calcium ion import
negative regulation of execution phase of apoptosis
negative regulation of intrinsic apoptotic signaling pathway
signal transduction
G-protein coupled receptor signaling pathway
feeding behavior
cell proliferation
cellular response to glucagon stimulus
